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No effect of polymorphisms in catechol-O-methyltransferase was found to generally be affiliated with postoperative oxycodone intake. The pharmacodynamics of oxycodone is mostly depending on polymorphic enzymes CYP2D6 and CP3A.Oxycodone is usually a semisynthetic μ- and κ-opioid receptor with agonist with a broad scope of use which include postop